MAO-A Phenotype Effects Response Sensitivity and the Parietal Old/New Effect during Recognition Memory

Frontiers in Human Neuroscience

卷:12

Tim Curran¹  Erika Nyhus²  Andrew Smolen³  Robert S. Ross⁴ 

[1] Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, United States;

[2] Department of Psychology and Program in Neuroscience, Bowdoin College, Brunswick, ME, United States;

[3] Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, United States;

[4] Neuroscience and Behavior Program, Department of Psychology, University of New Hampshire, Durham, NH, United States;

关键词: item memory;    source memory;    discriminability;    EEG;    ERP;   

DOI  :  10.3389/fnhum.2018.00053

来源: DOAJ

【 摘 要 】

A critical problem for developing personalized treatment plans for cognitive disruptions is the lack of understanding how individual differences influence cognition. Recognition memory is one cognitive ability that varies from person to person and that variation may be related to different genetic phenotypes. One gene that may impact recognition memory is the monoamine oxidase A gene (MAO-A), which influences the transcription rate of MAO-A. Examination of how MAO-A phenotypes impact behavioral and event-related potentials (ERPs) correlates of recognition memory may help explain individual differences in recognition memory performance. Therefore, the current study uses electroencephalography (EEG) in combination with genetic phenotyping of the MAO-A gene to determine how well-characterized ERP components of recognition memory, the early frontal old/new effect, left parietal old/new effect, late frontal old/new effect, and the late posterior negativity (LPN) are impacted by MAO-A phenotype during item and source memory. Our results show that individuals with the MAO-A phenotype leading to increased transcription have lower response sensitivity during both item and source memory. Additionally, during item memory the left parietal old/new effect is not present due to increased ERP amplitude for correct rejections. The results suggest that MAO-A phenotype changes EEG correlates of recognition memory and influences how well individuals differentiate between old and new items.

【 授权许可】

Unknown