Alternative parameterizations of relatedness in whole genome association analysis of pre-weaning traits of Nelore-Angus calves

Genetics and Molecular Biology

卷:37

Jason E. Sawyer¹  Andy D. Herring¹  David G. Riley¹  Clare A. Gill¹  James O. Sanders¹  Penny K. Riggs¹ 

[1] Texas A & M University;

关键词: birth weight;    gestation length;    weaning weight;    Nelore;    whole genome association;   

DOI  :  10.1590/S1415-47572014000400007

来源: DOAJ

【 摘 要 】

Gestation length, birth weight, and weaning weight of F2 Nelore-Angus calves (n = 737) with designed extensive full-sibling and half-sibling relatedness were evaluated for association with 34,957 SNP markers. In analyses of birth weight, random relatedness was modeled three ways: 1) none, 2) random animal, pedigree-based relationship matrix, or 3) random animal, genomic relationship matrix. Detected birth weight-SNP associations were 1,200, 735, and 31 for those parameterizations respectively; each additional model refinement removed associations that apparently were a result of the built-in stratification by relatedness. Subsequent analyses of gestation length and weaning weight modeled genomic relatedness; there were 40 and 26 trait-marker associations detected for those traits, respectively. Birth weight associations were on BTA14 except for a single marker on BTA5. Gestation length associations included 37 SNP on BTA21, 2 on BTA27 and one on BTA3. Weaning weight associations were on BTA14 except for a single marker on BTA10. Twenty-one SNP markers on BTA14 were detected in both birth and weaning weight analyses.

【 授权许可】

Unknown