Plasma epoxyeicosatrienoic acids and dihydroxyeicosatrieonic acids, insulin, glucose and risk of diabetes: The strong heart study

EBioMedicine

卷:66

Paul N Jensen¹  Barbara McKnight²  Jason G. Umans³  Maxwell Zeigler⁴  Rheem A. Totah⁴  Rozenn N. Lemaitre⁴  Sina A. Gharib⁴  Irena B. King⁵  Bruce M Psaty⁶  Amanda M. Fretts⁷  Julie Denham⁷  David S. Siscovick⁸  Barbara V. Howard⁹  Colleen M. Sitlani⁹  Nona Sotoodehnia¹⁰ 

[1] Corresponding author.;

[2] Georgetown and Howard Universities Center for Translational Science, Washington DC, USA;

[3] Cardiovascular Health Research Unit, Department of Epidemiology, University of Washington, Seattle, WA, USA;

[4] Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA;

[5] Department of Biostatistics, University of Washington, Seattle, WA, USA;

[6] Department of Internal Medicine, University of New Mexico, Albuquerque, NM, USA;

[7] Department of Medicinal Chemistry, University of Washington, Seattle, WA, USA;

[8] Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Washington, Seattle, WA, USA;

[9] MedStar Health Research Institute, Hyattsville, MD, USA;

[10] New York Academy of Medicine, New York, NY, USA;

关键词: Diabetes;    Epidemiology;    Epoxyeicosatrienoic acids;    Dihydroxyeicosatrieonic acids;    Insulin;    Glucose;   

DOI  :  

来源: DOAJ

【 摘 要 】

Background: Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid with multiple biological functions. Rodent experiments suggest EETs play a role in insulin sensitivity and diabetes, but evidence in humans is limited. To address this knowledge gap, we conducted a case-cohort study in the Strong Heart Family Study, a prospective cohort among American Indians. Methods: We measured 4 EET species and 4 species of corresponding downstream metabolites, dihydroxyeicosatrieonic acids (DHETs), in plasma samples from 1161 participants, including 310 with type 2 diabetes. We estimated the associations of total (esterified and free) EETs and DHETs with incident diabetes risk, adjusting for known risk factors. We also examined cross-sectional associations with plasma fasting insulin and glucose in the case-cohort and in 271 participants without diabetes from the older Strong Heart Study cohort, and meta-analyzed the results from the 2 cohorts. Findings: We observed no significant association of total EET or DHET levels with incident diabetes. In addition, plasma EETs were not associated with plasma insulin or plasma glucose. However, higher plasma 14,15-DHET was associated with lower plasma insulin and lower plasma glucose. Interpretation: In this first prospective study of EETs and diabetes, we found no evidence for a role of total plasma EETs in diabetes. The novel associations of 14,15-DHET with insulin and glucose warrant replication and exploration of possible mechanisms. Funding: US National Institutes of Health

【 授权许可】

Unknown