Development of a Phytomelatonin-Rich Extract from Cultured Plants with Excellent Biochemical and Functional Properties as an Alternative to Synthetic Melatonin

Antioxidants

卷:9

Salvador Zamora¹  Alberto Cuesta²  Francisca Pérez-Llamas³  MarinoB. Arnao³  Josefa Hernández-Ruiz⁴ 

[1] Histology, Faculty of Biology, University of Murcia, 30100 Murcia, Spain;

[2] Department of Cell Biology &

[3] Department of Physiology, Faculty of Biology, University of Murcia, 30100 Murcia, Spain;

[4] Department of Plant Biology, (Plant Physiology), Faculty of Biology, University of Murcia, 30100 Murcia, Spain;

关键词: food supplement;    jet-lag;    melatonin;    nutraceutical;    phytomelatonin;    sleep disorders;   

DOI  :  10.3390/antiox9020158

来源: DOAJ

【 摘 要 】

Melatonin is a pleiotropic molecule with multiple and various functions. In recent years, there has been a considerable increase in the consumption of melatonin supplements for reasons other than those related with sleep (as an antioxidant, for anti-aging, and as a hunger regulator). Although the chemical synthesis of melatonin has recently been improved, several unwanted by-products of the chemical reactions involved occur as contaminants. Phytomelatonin, melatonin of plant origin, was discovered in several plants in 1995, and the possibility of using raw plant material as a source to obtain dietary supplements rich in phytomelatonin instead of synthetic melatonin, with its corresponding chemical by-products was raised. This work characterizes the phytomelatonin-rich extract obtained from selected plant material and determines the contents in phytomelatonin, phenols, flavonoids, and carotenoids. Additionally, the antioxidant activity was measured. Finally, a melatonin-specific bioassay in fish was carried out to demonstrate the excellent biological properties of the natural phytomelatonin-rich extract obtained.

【 授权许可】

Unknown