Cannabinoids as Glial Cell Modulators in Ischemic Stroke: Implications for Neuroprotection

Frontiers in Pharmacology

卷:13

Andrés Vicente-Acosta²  Pilar Sobrino³  Maria Ceprian⁴  Frida Loría⁵  Maria Ruth Pazos⁵ 

[1] Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Madrid, Spain;

[2] Departamento de Biología Molecular, Universidad Autónoma de Madrid, Madrid, Spain;

[3] Departamento de Neurología, Hospital Universitario Fundación Alcorcón, Alcorcón, Spain;

[4] ERC Team, PGNM, INSERM U1315, CNRS UMR5261, University of Lyon 1, University of Lyon, Lyon, France;

[5] Laboratorio de Apoyo a la Investigación, Hospital Universitario Fundación Alcorcón, Alcorcón, Spain;

关键词: cannabinoids;    neuroinflammation;    ischemic stroke;    glia;    drug target;   

DOI  :  10.3389/fphar.2022.888222

来源: DOAJ

【 摘 要 】

Stroke is the second leading cause of death worldwide following coronary heart disease. Despite significant efforts to find effective treatments to reduce neurological damage, many patients suffer from sequelae that impair their quality of life. For this reason, the search for new therapeutic options for the treatment of these patients is a priority. Glial cells, including microglia, astrocytes and oligodendrocytes, participate in crucial processes that allow the correct functioning of the neural tissue, being actively involved in the pathophysiological mechanisms of ischemic stroke. Although the exact mechanisms by which glial cells contribute in the pathophysiological context of stroke are not yet completely understood, they have emerged as potentially therapeutic targets to improve brain recovery. The endocannabinoid system has interesting immunomodulatory and protective effects in glial cells, and the pharmacological modulation of this signaling pathway has revealed potential neuroprotective effects in different neurological diseases. Therefore, here we recapitulate current findings on the potential promising contribution of the endocannabinoid system pharmacological manipulation in glial cells for the treatment of ischemic stroke.

【 授权许可】

Unknown