The Functional Roles and Regulation of Circular RNAs during Cellular Stresses

Non-Coding RNA

卷:8

Ya-Chi Lin¹  Yueh-Chun Lee²  Wei-Yu Wang³  Yi-Ren Huang⁴  Kuei-Yang Hsiao⁵  Hui-Hsuan Lin⁵ 

[1] Department of Plant Pathology, College of Agriculture and Natural Resources, National Chung Hsing University, Taichung 40227, Taiwan;

[2] Department of Radiation Oncology, Chung Shan Medical University Hospital, Taichung 40201, Taiwan;

[3] Division of Hemato-Oncology, Department of Internal Medicine, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chia-Yi City 60002, Taiwan;

[4] Institute of Biochemistry, College of Life Sciences, National Chung Hsing University, Taichung 40227, Taiwan;

[5] Ph.D. Program in Tissue Engineering and Regenerative Medicine, National Chung Hsing University, Taichung 40227, Taiwan;

关键词: circRNA;    backsplicing;    DNA damage response;    genotoxic stress;    chemoresistance;    hypoxia;   

DOI  :  10.3390/ncrna8030038

来源: DOAJ

【 摘 要 】

Circular RNAs (circRNAs) are a novel class of regulatory RNA involved in many biological, physiological and pathological processes by functioning as a molecular sponge, transcriptional/epigenetic/splicing regulator, modulator of protein–protein interactions, and a template for encoding proteins. Cells are constantly dealing with stimuli from the microenvironment, and proper responses rely on both the precise control of gene expression networks and protein–protein interactions at the molecular level. The critical roles of circRNAs in the regulation of these processes have been heavily studied in the past decades. However, how the microenvironmental stimulation controls the circRNA biogenesis, cellular shuttling, translation efficiency and degradation globally and/or individually remains largely uncharacterized. In this review, how the impact of major microenvironmental stresses on the known transcription factors, splicing modulators and epitranscriptomic regulators, and thereby how they may contribute to the regulation of circRNAs, is discussed. These lines of evidence will provide new insight into how the biogenesis and functions of circRNA can be precisely controlled and targeted for treating human diseases.

【 授权许可】

Unknown