Susceptibility and Resistance Mechanisms During Photodynamic Therapy of Melanoma

Frontiers in Oncology

卷:10

Liu-Chang Tan¹  Li-Wen Dong¹  Wan-Qi Zhang¹  Yuan-Gang Lu¹  Xin-Ying Li¹  Xiao-Xiao Shen¹  Xiao Lu²  Hong Zheng² 

[1] Department of Plastic Surgery, Daping Hospital, Army Medical University, Chongqing, China;

[2] Department of Thoracic Surgery, Xinqiao Hospital, Army Medical University, Chongqing, China;

关键词: photodynamic therapy;    melanoma;    apoptosis;    autophagy;    tumor immunity;   

DOI  :  10.3389/fonc.2020.00597

来源: DOAJ

【 摘 要 】

Melanoma is the most aggressive malignant skin tumor and arises from melanocytes. The resistance of melanoma cells to various treatments results in rapid tumor growth and high mortality. As a local therapeutic modality, photodynamic therapy has been successfully applied for clinical treatment of skin diseases. Photodynamic therapy is a relatively new treatment method for various types of malignant tumors in humans and, compared to conventional treatment methods, has fewer side effects, and is more accurate and non-invasive. Although several in vivo and in vitro studies have shown encouraging results regarding the potential benefits of photodynamic therapy as an adjuvant treatment for melanoma, its clinical application remains limited owing to its relative inefficiency. This review article discusses the use of photodynamic therapy in melanoma treatment as well as the latest progress made in deciphering the mechanism of tolerance. Lastly, potential targets are identified that may improve photodynamic therapy against melanoma cells.

【 授权许可】

Unknown