Current Knowledge of MicroRNAs (miRNAs) in Acute Coronary Syndrome (ACS): ST-Elevation Myocardial Infarction (STEMI)

Life

卷:11

Minerva Codruta Badescu¹  Diana Popescu¹  Mariana Floria¹  Nicoleta Dima¹  Ciprian Rezus¹  Ana Roxana Ganceanu-Rusu¹  Evelina Maria Gosav¹  Daniela Maria Tanase¹  Anca Ouatu¹  Elena Rezus² 

[1] Department of Internal Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania;

[2] Department of Rheumatology and Physiotherapy, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania;

关键词: microRNA;    miRNA;    miR;    acute coronary syndrome;    STEMI;    myocardial infarction;   

DOI  :  10.3390/life11101057

来源: DOAJ

【 摘 要 】

Regardless of the newly diagnostic and therapeutic advances, coronary artery disease (CAD) and more explicitly, ST-elevation myocardial infarction (STEMI), remains one of the leading causes of morbidity and mortality worldwide. Thus, early and prompt diagnosis of cardiac dysfunction is pivotal in STEMI patients for a better prognosis and outcome. In recent years, microRNAs (miRNAs) gained attention as potential biomarkers in myocardial infarction (MI) and acute coronary syndromes (ACS), as they have key roles in heart development, various cardiac processes, and act as indicators of cardiac damage. In this review, we describe the current available knowledge about cardiac miRNAs and their functions, and focus mainly on their potential use as novel circulating diagnostic and prognostic biomarkers in STEMI.

【 授权许可】

Unknown