International Journal of Hematology-Oncology and Stem Cell Research | 卷:6 |
Recurrent Respiratory Papillomatosis: an Extensive Review | |
关键词: Human Papilloma Virus; Laryngeal; CO2 Laser; Cidofovir; Treatment; | |
DOI : | |
来源: DOAJ |
【 摘 要 】
Recurrent respiratory papillomatosis (RRP) is characterized by the recurrence of benign tumors (papillomata) inthe aero digestive tract caused by Human Papilloma Virus.The burden for the patient and the society is non negligible, due to the high frequency of repetitive surgeries.The disease follows a bimodal age distribution. Usually the very first manifestation is hoarseness or voice changes but if negligee it can causeairway obstructionresulting in respiratorystridor or acute respiratory distress The treatment is challenging, includes surgery (mostly CO2 laser) and adjuvant medical therapy is almost always required (Cidofovir, interferon a, and others). The risk of malignant transformation is not negligent. Advances in immunology will lead us to understand the biology of HPV and will permit successful therapies. Prophylactic HPV vaccines are a promising area of research concerning RRP
【 授权许可】
Unknown