Changes in plasma concentrations of edoxaban and coagulation biomarkers according to thromboembolic risk and atrial fibrillation type in patients undergoing catheter ablation: Subanalysis of KYU‐RABLE

Journal of Arrhythmia

卷:37

the KYU‐RABLE Investigators¹  Yasushi Mukai²  Atsushi Takita³  Tetsuji Shinohara⁴  Naohiko Takahashi⁴  Hideki Origasa⁵  Ken Okumura⁶  Keita Yamaguchi⁷  Tetsuya Kimura⁷ 

[1] ;

[2] Cardiology Division Japanese Red Cross Fukuoka Hospital Fukuoka Japan;

[3] Data Intelligence Department Daiichi Sankyo Co., Ltd Tokyo Japan;

[4] Department of Cardiology and Clinical Examination Faculty of Medicine Oita University Oita Japan;

[5] Division of Biostatistics and Clinical Epidemiology University of Toyama Graduate School of Medicine and Pharmaceutical Sciences Toyama Japan;

[6] Division of Cardiology Saiseikai Kumamoto Hospital Cardiovascular Center Kumamoto Japan;

[7] Medical Science Department Daiichi Sankyo Co., Ltd Tokyo Japan;

关键词: atrial fibrillation;    catheter ablation;    edoxaban;    hemorrhage;    thromboembolism;   

DOI  :  10.1002/joa3.12490

来源: DOAJ

【 摘 要 】

Abstract Background Catheter ablation (CA) for atrial fibrillation (AF) can be associated with a risk of thromboembolism and bleeding. We recently demonstrated that uninterrupted edoxaban with one dose delayed on the CA procedural day is associated with a low risk of periprocedural complications. Previous reports have indicated that some specific subgroups of patients undergoing CA have an increased risk of bleeding and thromboembolic complications. This subanalysis of the KYU‐RABLE study assessed the changes in plasma concentrations of edoxaban and coagulation biomarkers during the periprocedural period of CA in subgroups stratified by the risk of thromboembolism assessed by CHADS2 score (<2 or ≥2) and AF type (paroxysmal AF [PAF] or non‐PAF). Methods We evaluated changes in plasma concentrations of edoxaban and coagulation biomarkers (D‐dimer and prothrombin fragment F1+2), by subgroup, during the periprocedural period of CA. Measurements were made prior to CA (procedure day). Results This subanalysis evaluated data from 343 patients with CHADS2 score <2 and 134 patients with CHADS2 score ≥2, and from 280 patients with PAF and 197 patients with non‐PAF. Plasma edoxaban concentration decreased with time on the day of CA, while plasma concentrations of coagulation biomarkers remained unchanged. No significant differences were observed according to CHADS2 score or type of AF. Conclusions The changes in plasma concentrations of edoxaban and coagulation biomarkers in each subgroup were similar to those of the whole analysis, regardless of the thromboembolic risk (CHADS2 <2 or ≥2) or AF type (PAF or non‐PAF).

【 授权许可】

Unknown