Entropy Metrics Correlating with Higher Residual Functioning in Patients with Chronic Disorders of Consciousness

Brain Sciences

卷:12

Davide Rossi Sebastiano¹  Gianvittorio Luria¹  Silvana Franceschetti¹  Stefania Ferraro¹  Elisa Visani¹  Ferruccio Panzica¹  Matilde Leonardi¹  Davide Sattin² 

[1] Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133 Milano, Italy;

[2] IRCCS Istituti Clinici Scientifici Maugeri di Milano, Via Camaldoli 64, 20138 Milano, Italy;

关键词: disorders of consciousness;    EEG;    entropy;   

DOI  :  10.3390/brainsci12030332

来源: DOAJ

【 摘 要 】

To test the ability of different entropy measures to classify patients with different conditions of chronic disorder of consciousness, we applied the Lempel–Ziv complexity, the amplitude coalition entropy (ACE), and the synchrony coalition entropy (SCE) to the EEG signals recorded in 32 patients, clinically evaluated using the coma recovery scale revised (CRS-R). All the entropy measures indicated that differences found in the theta and alpha bands can distinguish patients in a minimal consciousness state (MCS) with respect to those in a vegetative state/unresponsive wakefulness state (VS/UWS). These differences were significant comparing the entropy measure performed on the anterior region of the left hemisphere and midline region. The values of theta-alpha entropy positively correlated with those of the CRS-R scores. Among the entropy measures, ACE most often highlighted significant differences. The higher values found in MCS were for the less impaired patients, according to their CRS-R, suggest that the preservation of signal entropy on the anterior region of the dominant hemisphere correlates with better preservation of consciousness, even in chronic conditions.

【 授权许可】

Unknown