Regioselective chlorination and bromination of unprotected anilines under mild conditions using copper halides in ionic liquids

Beilstein Journal of Organic Chemistry

卷:8

Nurbiya Nurahmat¹  He Zhang¹  Zhihua Sun¹  Chao Wei¹  Ya Li¹  Yan Shao¹  Kun Wen¹  Yongjia Shen²  Han Wang² 

[1] College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai, 201620, China;

[2] School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, 200237, China;

关键词: halogenation;    ionic liquids;    oxydation;    regioselectivity;    solvent effects;   

DOI  :  10.3762/bjoc.8.84

来源: DOAJ

【 摘 要 】

By using ionic liquids as solvents, the chlorination or bromination of unprotected anilines at the para-position can be achieved in high yields with copper halides under mild conditions, without the need for potentially hazardous operations such as supplementing oxygen or gaseous HCl.

【 授权许可】

Unknown