Current Applications and Future Directions of Bioengineering Approaches for Bladder Augmentation and Reconstruction

Frontiers in Surgery

卷:8

Xuesheng Wang³  Fan Zhang³  Limin Liao³ 

[1] Department of Urology, Capital Medical University, Beijing, China;

[2] Department of Urology, China Rehabilitation Research Center, Rehabilitation School of Capital Medical University, Beijing, China;

[3] University of Rehabilitation, Qingdao, China;

关键词: bladder augmentation;    scaffolds;    tissue engineering;    3D bioprinting;    bladder reconstruction;   

DOI  :  10.3389/fsurg.2021.664404

来源: DOAJ

【 摘 要 】

End-stage neurogenic bladder usually results in the insufficiency of upper urinary tract, requiring bladder augmentation with intestinal tissue. To avoid complications of augmentation cystoplasty, tissue-engineering technique could offer a new approach to bladder reconstruction. This work reviews the current state of bioengineering progress and barriers in bladder augmentation or reconstruction and proposes an innovative method to address the obstacles of bladder augmentation. The ideal tissue-engineered bladder has the characteristics of high biocompatibility, compliance, and specialized urothelium to protect the upper urinary tract and prevent extravasation of urine. Despite that many reports have demonstrated that bioengineered bladder possessed a similar structure to native bladder, few large animal experiments, and clinical applications have been performed successfully. The lack of satisfactory outcomes over the past decades may have become an important factor hindering the development in this field. More studies should be warranted to promote the use of tissue-engineered bladders in clinical practice.

【 授权许可】

Unknown