Increased Variation in Body Weight and Food Intake Is Related to Increased Dietary Fat but Not Increased Carbohydrate or Protein in Mice

Frontiers in Nutrition

卷:9

Sumei Hu¹  John R. Speakman²  Yingga Wu³  Lu Wang³  Guanlin Wang³  Min Li⁴  Chaoqun Niu⁴  Xueying Zhang⁴  Yanchao Xu⁵  Dengbao Yang⁵  Li Li⁶  Baoguo Li⁶  Jianbo Li⁷ 

[1] Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Engineering and Technology Research Center of Food Additives, National Soybean Processing Industry Technology Innovation Center, Beijing, China;

[2] CAS Center of Excellence in Animal Evolution and Genetics, Kunming, China;

[3] Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen, United Kingdom;

[4] Shenzhen Key Laboratory of Metabolic Health, Center for Energy Metabolism and Reproduction, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China;

[5] State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China;

[6] University of Chinese Academy of Sciences, Beijing, China;

[7] University of Dali, Dali, China;

关键词: protein;    fat;    carbohydrate;    mice;    strain;    variation;   

DOI  :  10.3389/fnut.2022.835536

来源: DOAJ

【 摘 要 】

A variety of inbred mouse strains have been used for research in metabolic disorders. Despite being inbred, they display large inter-individual variability for many traits like food intake and body weight. However, the relationship between dietary macronutrients and inter-individual variation in body weight and food intake of different mouse strains is still unclear. We investigated the association between macronutrient content of the diet and variations in food intake, body composition, and glucose tolerance by exposing five different mouse strains (C57BL/6, BALB/c, C3H, DBA/2, and FVB) to 24 different diets with variable protein, fat, and carbohydrate contents. We found only increasing dietary fat, but not protein or carbohydrate had a significant association (positive) with variation in both food intake and body weight. The highest variation in both body weight and food intake occurred with 50% dietary fat. However, there were no significant relationships between the variation in fat and lean mass with dietary protein, fat, or carbohydrate levels. In addition, none of the dietary macronutrients had significant impacts on the variation in glucose tolerance ability in C57BL/6 mice. In conclusion, the variations in food intake and body weight changes increased with the elevation of dietary fat levels.

【 授权许可】

Unknown