Alpha-Arbutin Promotes Wound Healing by Lowering ROS and Upregulating Insulin/IGF-1 Pathway in Human Dermal Fibroblast

Frontiers in Physiology

卷:11

Vanessa Ludwig¹  Oliver Heeb²  Tatsukata Kawagoe³  Nobuhisa Mizuki³  Akira Meguro³  Natalia Polouliakh⁴ 

[1] Department of Biology, ETH Zürich, Zurich, Switzerland;

[2] Department of MAVT, ETH Zürich, Zurich, Switzerland;

[3] Department of Ophthalmology and Visual Sciences, Yokohama City University Graduate School of Medicine, Yokohama, Japan;

[4] Scientista Co., Ltd., Tokyo, Japan;

[5] Sony Computer Science Laboratories Inc., Tokyo, Japan;

关键词: alpha-arbutin;    gene expression;    phylogenetic footprinting;    anti-oxidative activities;    Nrf2-signaling;   

DOI  :  10.3389/fphys.2020.586843

来源: DOAJ

【 摘 要 】

Alpha-arbutin (4-hydroxyphenyl alpha-glucopyranoside) is a known inhibitor of tyrosinase in keratinocytes; however, its effect on other genes and pathways in other skin cells has not been thoroughly investigated. In this study, we investigate the mechanism of alpha-arbutin activity in human dermal fibroblast cultures for 48 h. Results showed that the oxidative stress pathway was activated as alpha-arbutin reduced reactive oxygen species. In addition, we found a high possibility of wound healing and the upregulation of the insulin-like growth factor 1 receptor (IFG1R) pathway. We also investigated the role of the NRF2 gene in mediating the alpha-arbutin response. In silico comparative genomics analysis conducted using our original tool, SHOE, suggested transcription factors with a role in tumor suppression and toxicity response as candidates for regulating the alpha-arbutin–mediated pathway.

【 授权许可】

Unknown