Mosquito Trilogy: Microbiota, Immunity and Pathogens, and Their Implications for the Control of Disease Transmission

Frontiers in Microbiology

卷:12

Irene Arnoldi²  Giulia Barbieri²  Sara Epis³  Ilaria Varotto-Boccazzi³  Paolo Gabrieli³  Silvia Caccia⁴  Francesco Comandatore⁵ 

[1] Department of Agricultural Sciences, University of Naples “Federico II”, Naples, Italy;

[2] Department of Biology and Biotechnology, University of Pavia, Pavia, Italy;

[3] Department of Biosciences and Pediatric Clinical Research Center “Romeo ed Enrica Invernizzi”, University of Milan, Milan, Italy;

[4] Task Force on Microbiome Studies, University of Naples “Federico II”, Naples, Italy;

[5] “L. Sacco” Department of Biomedical and Clinical Sciences, Pediatric Clinical Research Center “Romeo ed Enrica Invernizzi”, University of Milan, Milan, Italy;

关键词: Wolbachia;    vector-borne diseases;    control strategies;    pathogens;    insects;   

DOI  :  10.3389/fmicb.2021.630438

来源: DOAJ

【 摘 要 】

In mosquitoes, the interaction between the gut microbiota, the immune system, and the pathogens that these insects transmit to humans and animals is regarded as a key component toward the development of control strategies, aimed at reducing the burden of severe diseases, such as malaria and dengue fever. Indeed, different microorganisms from the mosquito microbiota have been investigated for their ability to affect important traits of the biology of the host insect, related with its survival, development and reproduction. Furthermore, some microorganisms have been shown to modulate the immune response of mosquito females, significantly shaping their vector competence. Here, we will review current knowledge in this field, focusing on i) the complex interaction between the intestinal microbiota and mosquito females defenses, both in the gut and at humoral level; ii) how knowledge on these issues contributes to the development of novel and targeted strategies for the control of mosquito-borne diseases such as the use of paratransgenesis or taking advantage of the relationship between Wolbachia and mosquito hosts. We conclude by providing a brief overview of available knowledge on microbiota-immune system interplay in major insect vectors.

【 授权许可】

Unknown