Two Adult Patients with Ectopic Neurohypophysis and Panhypopituitarism Due to Absent Pituitary Stalk

Turkish Journal of Endocrinology and Metabolism

卷:18

Fatih Kılıçlı¹  Hatice Sebila Dökmetaş²  Fettah Acıbucu³ 

[1] Cumhuriyet University Faculty of Medicine, Department of Endocrinology and Metabolism, Sivas, Turkey;

[2] Medipol University Faculty of Medicine, Department of Endocrinology and Metabolism, İstanbul, Turkey;

[3] Sivas Numune Hospital, Clinic of Endocrinology and Metabolism, Sivas, Turkey;

关键词: Ectopic neurohypophysis;    panhypopituitarism;    absent pituitary stalk;   

DOI  :  10.4274/tjem.2485

来源: DOAJ

【 摘 要 】

We report two cases of 27-year-old and 19-year-old female patients with ectopic neurohypophysis and panhypopituitarism due to absent pituitary stalk. They were admitted to the endocrinology clinic with short stature, growth retardation and primary amenorrhea. Basal hormones revealed secondary hypothyroidism, adrenal insufficiency, hypogonadism and growth hormone insufficiency. Peak cortisol response to the short synacthen test (SST) was normal but was inadequate to insulin tolerance test. The other dynamic pituitary function tests showed panhypopituitarism. Magnetic resonance imaging of the pituitary gland revealed an ectopic posterior pituitary tissue and absent pituitary stalk. We administered hormone replacement therapy. As this disorder is usually encountered in the pediatric age group, we report here two adult patients with ectopic posterior pituitary tissue, absent pituitary stalk and panhypopituitarism.

【 授权许可】

Unknown