Adaptive sliding mode control of HIV-1 infection model

Informatics in Medicine Unlocked

卷:25

S. Hadipour Lakmesari¹  M.J. Mahmoodabadi² 

[1] Department of Mechanical Engineering, Sirjan University of Technology, Sirjan, Iran;

[2] Corresponding author.;

关键词: HIV-1 model;    Infection theory;    Sliding mode control;    Gradient descent method;    Adaptive approach;   

DOI  :  

来源: DOAJ

【 摘 要 】

In modern times, the human immunodeficiency virus (HIV), as a deadly pathogen, imposes harmful effects on human health. Thus, scholars have presented a large body of research on the topic, such as developing an antiretroviral treatment for this viral infection. This study considers a three-state dynamical model of HIV and applies a robust adaptive stabilizer based on a sliding mode controller (SMC) and gradient descent laws for it. To be more precise, the paper presents a control scheme to enhance the number of the CD4+ T cells and reduce the number of the infected CD4+ T cells and free virus particles through the control of the reverse transcriptase inhibitors (RTIs). For this purpose, the sliding mode control is designed for the HIV-1 dynamical system. Then, the gradient descent law is employed to update the control gains. The results reflect the desired performance of the proposed control strategy by presenting a smooth control input and suitable time responses.

【 授权许可】

Unknown