Influenza Virus Infects and Depletes Activated Adaptive Immune Responders

Advanced Science

卷:8

Bruce A. Davidson¹  Paul Knight¹  Jonathan F. Lovell²  Blaine A. Pfeifer³  Suresh K. Mittal⁴  Adolfo García‐Sastre⁵  Samuel Amoah⁶  Zachary Ende⁶  Priya Ranjan⁶  Suryaprakash Sambhara⁶  Margarita Mishina⁶  Caitlin D. Bohannon⁶  Shivaprakash Gangappa⁶  Weiping Cao⁶  Amrita Kumar⁶  Wadzanai P. Mboko⁶ 

[1] Department of Anesthesiology Jacobs School of Medicine and Biomedical Sciences State University of New York at Buffalo Buffalo NY 14260 USA;

[2] Department of Biomedical Engineering State University of New York at Buffalo Buffalo NY 14260 USA;

[3] Department of Chemical and Biological Engineering School of Engineering and Applied Sciences State University of New York at Buffalo Buffalo NY 14260 USA;

[4] Department of Comparative Pathobiology and Purdue Institute for Inflammation Immunology and Infectious Disease Purdue University West Lafayette IN 47907 USA;

[5] Global Health and Emerging Pathogens Institute Icahn School of Medicine at Mount Sinai New York NY 10029 USA;

[6] Influenza Division Centers for Disease Control and Prevention Atlanta GA 30329 USA;

关键词: adenovirus;    flowcytometry;    immunosuppression;    influenza;    pneumococcus;   

DOI  :  10.1002/advs.202100693

来源: DOAJ

【 摘 要 】

Abstract Influenza infections cause several million cases of severe respiratory illness, hospitalizations, and hundreds of thousands of deaths globally. Secondary infections are a leading cause of influenza's high morbidity and mortality, and significantly factored into the severity of the 1918, 1968, and 2009 pandemics. Furthermore, there is an increased incidence of other respiratory infections even in vaccinated individuals during influenza season. Putative mechanisms responsible for vaccine failures against influenza as well as other respiratory infections during influenza season are investigated. Peripheral blood mononuclear cells (PBMCs) are used from influenza vaccinated individuals to assess antigen‐specific responses to influenza, measles, and varicella. The observations made in humans to a mouse model to unravel the mechanism is confirmed and extended. Infection with influenza virus suppresses an ongoing adaptive response to vaccination against influenza as well as other respiratory pathogens, i.e., Adenovirus and Streptococcus pneumoniae by preferentially infecting and killing activated lymphocytes which express elevated levels of sialic acid receptors. These findings propose a new mechanism for the high incidence of secondary respiratory infections due to bacteria and other viruses as well as vaccine failures to influenza and other respiratory pathogens even in immune individuals due to influenza viral infections.

【 授权许可】

Unknown