Longitudinal and Transverse Relaxivity Analysis of Native Ferritin and Magnetoferritin at 7 T MRI

International Journal of Molecular Sciences

卷:22

Oliver Strbak¹  Jan Gombos²  Martina Kmetova²  Dusan Dobrota²  Peter Kopcansky³  Jozef Kovac³  Lucia Balejcikova⁴ 

[1] Biomedical Center Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Mala Hora 4, 036 01 Martin, Slovakia;

[2] Department of Medical Biochemistry, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Mala Hora 4, 036 01 Martin, Slovakia;

[3] Institute of Experimental Physics, Slovak Academy of Sciences, Watsonova 47, 040 01 Kosice, Slovakia;

[4] Institute of Hydrology, Slovak Academy of Sciences, Dubravska Cesta 9, 841 04 Bratislava, Slovakia;

关键词: native ferritin;    magnetoferritin;    loading factor;    MRI;    relaxation;    longitudinal and transverse relaxivity;   

DOI  :  10.3390/ijms22168487

来源: DOAJ

【 摘 要 】

Magnetite mineralization in human tissue is associated with various pathological processes, especially neurodegenerative disorders. Ferritin’s mineral core is believed to be a precursor of magnetite mineralization. Magnetoferritin (MF) was prepared with different iron loading factors (LFs) as a model system for pathological ferritin to analyze its MRI relaxivity properties compared to those of native ferritin (NF). The results revealed that MF differs statistically significantly from NF, with the same LF, for all studied relaxation parameters at 7 T: r₁, r₂, r₂*, r₂/r₁, r₂*/r₁. Distinguishability of MF from NF may be useful in non-invasive MRI diagnosis of pathological processes associated with iron accumulation and magnetite mineralization (e.g., neurodegenerative disorders, cancer, and diseases of the heart, lung and liver). In addition, it was found that MF samples possess very strong correlation and MF’s relaxivity is linearly dependent on the LF, and the transverse and longitudinal ratios r₂/r₁ and r₂*/r₁ possess complementary information. This is useful in eliminating false-positive hypointensive artefacts and diagnosis of the different stages of pathology. These findings could contribute to the exploitation of MRI techniques in the non-invasive diagnosis of iron-related pathological processes in human tissue.

【 授权许可】

Unknown