Community-based intermittent mass testing and treatment for malaria in an area of high transmission intensity, western Kenya: study design and methodology for a cluster randomized controlled trial

Malaria Journal

卷:16

Kephas Otieno¹  Tony Sang¹  Wycliffe Odongo¹  Benard Abong’o¹  Simon Kariuki¹  David Obor¹  Florence Were¹  Nobert Awino¹  Vincent Were¹  Laurence Slutsker²  Kim A. Lindblade²  S. Patrick Kachur²  Mary J. Hamel²  Meghna Desai²  Aaron M. Samuels²  John Williamson²  John Gimnig²  Denise Roth Allen²  Ya Ping Shi² 

[1] Centre for Global Health Research, Kenya Medical Research Institute;

[2] Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention;

关键词: Mass test and treat;    Malaria;    Asymptomatic infections;    Transmission reduction;    Kenya;    Study design;   

DOI  :  10.1186/s12936-017-1883-z

来源: DOAJ

【 摘 要 】

Abstract Most human Plasmodium infections in western Kenya are asymptomatic and are believed to contribute importantly to malaria transmission. Elimination of asymptomatic infections requires active treatment approaches, such as mass testing and treatment (MTaT) or mass drug administration (MDA), as infected persons do not seek care for their infection. Evaluations of community-based approaches that are designed to reduce malaria transmission require careful attention to study design to ensure that important effects can be measured accurately. This manuscript describes the study design and methodology of a cluster-randomized controlled trial to evaluate a MTaT approach for malaria transmission reduction in an area of high malaria transmission. Ten health facilities in western Kenya were purposively selected for inclusion. The communities within 3 km of each health facility were divided into three clusters of approximately equal population size. Two clusters around each health facility were randomly assigned to the control arm, and one to the intervention arm. Three times per year for 2 years, after the long and short rains, and again before the long rains, teams of community health volunteers visited every household within the intervention arm, tested all consenting individuals with malaria rapid diagnostic tests, and treated all positive individuals with an effective anti-malarial. The effect of mass testing and treatment on malaria transmission was measured through population-based longitudinal cohorts, outpatient visits for clinical malaria, periodic population-based cross-sectional surveys, and entomological indices.

【 授权许可】

Unknown