Preparation and characterization of guar gum based biopolymeric hydrogels for controlled release of antihypertensive drug

Arabian Journal of Chemistry

卷:14

Dure Najaf Iqbal¹  Ambreen Ghani²  Munawar Iqbal²  Erum Akbar Hussain³  Mahnoor Jan Muhammad⁴  Hina Daud⁵  Arif Nazir⁵  Nasir Ahmad⁶  Saliha Nazir⁷ 

[1] Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104, United States;

[2] Roy &

[3] Technology, Islamabad, Pakistan;

[4] Department of Biomedical Engineering and Sciences, School of Mechanical and Manufacturing Engineering, National University of Science &

[5] Department of Chemistry, Lahore College for Women University, Lahore 54000, Pakistan;

[6] Department of Chemistry, University of Education Lahore, Vehari Campus 61100, Pakistan;

[7] Department of Chemistry, University of Lahore, Lahore 53700, Pakistan;

关键词: Guar gum;    Hydrogels;    Solution casting technique;    Anti-hypertensive drug;    Controlled drug release;   

DOI  :  

来源: DOAJ

【 摘 要 】

Rapid release and poor drug encapsulation ability limit the use of single biopolymer in water-soluble drugs loading, carrying and release efficiency. In the present study, blended hydrogels based on guar gum, sodium alginate and polyvinyl alcohol (GG/SA/PVA) were prepared by solution casting technique and employed for controlled release of verapamil HCl (VP-HCl). The extent of interaction of all blends was explored by Fourier-transform infrared spectroscopy (FTIR) while surface morphology was determined by Atomic force microscope (AFM) and Scanning electron microscope (SEM). The crystallinity, thermal stability and water absorbing capacity of blends were studied by X-ray diffraction (XRD), Differential scanning calorimeter (DSC), thermogravimetric analysis (TGA) and swelling studies respectively. The results revealed improved crystallinity and stability of all the blends. The prepared blends showed promising drug loading and releasing efficiency with higher GG contents for the controlled release of verapamil HCl and at pH 7.4. Optimum drug release (94%) drug release was achieved in 12 h and followed non-Fickian diffusion mechanism. It has been concluded from the results that GG/SA/PVA blends have potential for drug delivery applications in a controlled manner.

【 授权许可】

Unknown