Clinical, Radiological, and Histopathological Characteristics of Periosteal Chondrosarcoma with a Focus on the Frequency of Medullary Invasion

Journal of Clinical Medicine

卷:11

Yuichi Yamada¹  Yosuke Susuki¹  Kenichi Kohashi¹  Hidetaka Yamamoto¹  Yoshinao Oda¹  Toshifumi Fujiwara²  Yasuharu Nakashima²  Yoshihiro Matsumoto²  Keiichiro Iida²  Makoto Nakagawa²  Akira Nabeshima²  Makoto Endo²  Nobuhiko Yokoyama³  Ryohei Yokoyama³  Nokitaka Setsu³  Yukihide Iwamoto⁴  Tomoya Matsunobu⁴  Akira Maekawa⁴ 

[1] Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka 812-8582, Japan;

[2] Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka 812-8582, Japan;

[3] Department of Orthopaedic Surgery, Kyushu Cancer Center, 3-1-1, Notame, Minami-ku, Fukuoka 811-1395, Japan;

[4] Department of Orthopaedic Surgery, Kyushu Rosai Hospital, 1-1, Sonekita, Kokuraminami-ku, Kitakyushu 800-0296, Japan;

关键词: periosteal chondrosarcoma;    medullary invasion;    MRI;    wide resection;    surgery planning;    histologically negative margin;   

DOI  :  10.3390/jcm11072062

来源: DOAJ

【 摘 要 】

Periosteal chondrosarcoma is an extremely rare malignant cartilage-forming tumour that originates from the periosteum and occurs on the surface of bone. Often, it is difficult to distinguish periosteal chondrosarcoma from other tumours, and reports in the literature are scarce. This study aims to investigate the characteristics of periosteal chondrosarcoma, focusing particularly on medullary invasion. Among 33 periosteal cartilaginous tumours, seven patients with pathologically proven periosteal chondrosarcoma were identified retrospectively. The average tumour size was 5.4 cm in the long axis; two tumours were smaller than 3.0 cm. Six tumours were resected with a wide margin, and the remaining tumour had a marginal margin. Histology revealed that six tumours (85.7%) had invaded the medullary cavity; three of these did not show invasion into the medullary cavity on MRI evaluation. Neither local recurrence nor metastasis was observed among these patients. The frequency of invasion of the medullary cavity was higher than that reported previously. The recommended treatment for periosteal chondrosarcoma is resection with an adequate margin. Therefore, surgeons should consider the possibility of medullary invasion when attempting to achieve a histologically negative margin, even if the tumour does not show invasion into the medullary cavity on MRI.

【 授权许可】

Unknown