Chemically Modified Biomimetic Carbon-Coated Iron Nanoparticles for Stent Coatings: In Vitro Cytocompatibility and In Vivo Structural Changes in Human Atherosclerotic Plaques

Biomedicines

卷:9

Sascha Balakin¹  Joerg Opitz¹  Natalia Beshchasna¹  Rosa Karen Carreon Paz¹  Benjamin Kruppke²  Hans-Peter Wiesmann²  Pavel Postnikov³  Marina Trusova³  Yulia Rogovskaya⁴  Sergey Afanasyev⁴  Kristina Kopeva⁴  Shamil Akhmedov⁴  Sergey Popov⁴  Elena Grakova⁴ 

[1] Fraunhofer Institute for Ceramic Technologies and Systems IKTS, 01109 Dresden, Germany;

[2] Max Bergmann Center of Biomaterials, Institute of Materials Science, Technische Universität Dresden, 01069 Dresden, Germany;

[3] Research School of Chemistry and Applied Biomedical Sciences, Tomsk Polytechnic University, 634050 Tomsk, Russia;

[4] Tomsk National Research Medical Center of the Russian Academy of Sciences, Cardiology Research Institute, 634012 Tomsk, Russia;

关键词: atherosclerosis;    high density lipoprotein;    chemically modified carbon-coated iron nanoparticle;    reverse cholesterol transport;    macrophage;    coronary stent;   

DOI  :  10.3390/biomedicines9070802

来源: DOAJ

【 摘 要 】

Atherosclerosis, a systematic degenerative disease related to the buildup of plaques in human vessels, remains the major cause of morbidity in the field of cardiovascular health problems, which are the number one cause of death globally. Novel atheroprotective HDL-mimicking chemically modified carbon-coated iron nanoparticles (Fe@C NPs) were produced by gas-phase synthesis and modified with organic functional groups of a lipophilic nature. Modified and non-modified Fe@C NPs, immobilized with polycaprolactone on stainless steel, showed high cytocompatibility in human endothelial cell culture. Furthermore, after ex vivo treatment of native atherosclerotic plaques obtained during open carotid endarterectomy surgery, Fe@C NPs penetrated the inner structures and caused structural changes of atherosclerotic plaques, depending on the period of implantation in Wistar rats, serving as a natural bioreactor. The high biocompatibility of the Fe@C NPs shows great potential in the treatment of atherosclerosis disease as an active substance of stent coatings to prevent restenosis and the formation of atherosclerotic plaques.

【 授权许可】

Unknown