A Facile Ionic Liquid Promoted Synthesis, Cholinesterase Inhibitory Activity and Molecular Modeling Study of Novel Highly Functionalized Spiropyrrolidines

Molecules

卷:20

Abdulrahman I. Almansour¹  Natarajan Arumugam¹  Raju Suresh Kumar¹  Mehvish Farooq²  Mohamed Ashraf Ali³  Yalda Kia⁴  Alireza Basiri⁵  Vikneswaran Murugaiyah⁵ 

[1] Department of Chemistry, College of Science, King Saud University, P.O. Box 2455,Riyadh 11451, Saudi Arabia;

[2] Institute of Pharmaceutical Science, King's College London, London SE1 9NH, UK;

[3] Pharmacogenetic and Novel Therapeutic Institute for Research in Molecular Medicine,Universiti Sains Malaysia, Minden 11800, Malaysia;

[4] School of Chemical Sciences, Universiti Sains Malaysia, Minden 11800, Malaysia;

[5] School of Pharmaceutical Sciences, Universiti Sains Malaysia, Minden 11800, Malaysia;

关键词: acetylcholinesterase (AChE), butyrylcholinesterase (BChE), Alzheimer’s disease (AD), spiropyrrolidines, ionic liquid and molecular docking study;   

DOI  :  10.3390/molecules20022296

来源: DOAJ

【 摘 要 】

A series of novel dimethoxyindanone embedded spiropyrrolidines were synthesized in ionic liquid, [bmim]Br and were evaluated for their inhibitory activities towards cholinesterases. Among the spiropyrrolidines, compound 4f exhibited the most potent activity with an IC50 value of 1.57 µM against acethylcholinesterase (AChE). Molecular docking simulation for the most active compound was employed with the aim of disclosing its binding mechanism to the active site of AChE receptor.

【 授权许可】

Unknown