Evaluation of calcification resistance of xenopericardium treated with polyhydroxy compounds

Vestnik Transplantologii i Iskusstvennyh Organov

卷:23

T. V. Glushkova¹  Yu. A. Kudryavtseva¹  E. A. Ovcharenko¹  M. A. Rezvova¹  L. S. Barbarash¹ 

[1] Research Institute for Complex Issues of Cardiovascular Diseases;

关键词: xenopericardium;    polyvinyl alcohol;    tannic acid;    ethylene glycol diglycidyl ether;    glutaraldehyde;    calcification;   

DOI  :  10.15825/1995-1191-2021-1-75-83

来源: DOAJ

【 摘 要 】

Calcification of biomaterials used in prosthetic heart valves has been a challenging issue in cardiovascular surgery. The objective of this work is to compare the efficiency of polyvinyl alcohol (PVA) and tannic acid (TA) modification of xenomaterials, pre-stabilized with glutaraldehyde (GA) and ethylene glycol diglycidyl ether (EGDE), in reducing calcification. Analysis of mechanical properties evaluated under uniaxial tension, showed a significant increase in the tensile strength of the test samples compared to the control (unmodified) samples (p < 0.05). Additional treatment of GA-fixed tissue with PVA and TA significantly reduced the amount of calcium in the samples implanted into rats for a 60-day follow-up (p < 0.05). The level of calcification of samples prestabilized with EGDE and treated with PVA and TA did not differ from the control group (p = 0.063). Cumulative analysis of the study results demonstrated that the GA-fixed biomaterial modified with PVA and TA can reduce calcium-binding activity and increase strength. This indicates the prospects for clinical application of the proposed treatment methods. This being said, the issue of long-term body response requires further study of the long-term stability of the modified biomaterial under physiologic blood flow conditions.

【 授权许可】

Unknown