Lower urinary tract transitional cell carcinoma in cats: Clinical findings, treatments, and outcomes in 118 cases

Journal of Veterinary Internal Medicine

卷:34

Milan Milovancev¹  Joanne Tuohy²  Kyle Mathews³  Jonathan Hash³  Mandy L. Wallace⁴  Laura E. Selmic⁵  Cassie N. Lux⁶  Ameet Singh⁷  Philipp D. Mayhew⁸  William T. N. Culp⁸  Robert B. Rebhun⁸  Michelle A. Giuffrida⁸  Ingrid M. Balsa⁸  Peter Ellis⁸  Jenna H. Burton⁸  Michael S. Kent⁸  Carrie A. Palm⁸  Michele A. Steffey⁸  Maureen A. Griffin⁸  James A. Perry⁹  Allison Gedney⁹  Julius M. Liptak¹⁰ 

[1] Carlson College of Veterinary Medicine Oregon State University Corvallis Oregon;

[2] College of Veterinary Medicine Colorado State University Fort Collins Colorado;

[3] College of Veterinary Medicine North Carolina State University Raleigh North Carolina;

[4] College of Veterinary Medicine University of Georgia Athens Georgia;

[5] College of Veterinary Medicine University of Illinois Urbana Illinois;

[6] College of Veterinary Medicine University of Tennessee Knoxville Tennessee;

[7] Ontario Veterinary College University of Guelph Guelph Ontario Canada;

[8] School of Veterinary Medicine University of California‐Davis Davis California;

[9] School of Veterinary Medicine University of Pennsylvania Philadelphia Pennsylvania;

[10] VCA Canada—Alta Vista Animal Hospital Ottawa Ontario Canada;

关键词: bladder;    cat;    cystectomy;    neoplasia;    urethra;   

DOI  :  10.1111/jvim.15656

来源: DOAJ

【 摘 要 】

Abstract Background Lower urinary tract transitional cell carcinoma (TCC) is an important but rarely described disease of cats. Objectives To report the clinical characteristics, treatments, and outcomes in a cohort of cats with lower urinary tract TCC and to test identified variables for prognostic relevance. Animals One‐hundred eighteen client‐owned cats with lower urinary tract carcinoma. Methods Medical records were retrospectively reviewed to obtain information regarding clinical characteristics, treatments, and outcomes. Recorded variables were analyzed statistically. Results Median age of affected cats was 15 years (range, 5.0‐20.8 years) and median duration of clinical signs was 30 days (range, 0‐730 days). The trigone was the most common tumor location (32/118; 27.1%) as assessed by ultrasound examination, cystoscopy, or both. Treatment was carried out in 73 of 118 (61.9%) cats. Metastatic disease was documented in 25 of 118 (21.2%) cats. Median progression‐free survival and survival time for all cats were 113 days (95% confidence interval [CI], 69‐153) and 155 days (95% CI, 110‐222), respectively. Survival increased significantly (P < .001) when comparing cats across the ordered treatment groups: no treatment, treatment without partial cystectomy, and treatment with partial cystectomy. Partial cystectomy (hazard ratio [HR], 0.31; 95% CI, 0.17‐0.87) and treatment with nonsteroidal anti‐inflammatory drugs (HR, 0.55; 95% CI, 0.33‐0.93) were significantly associated with longer survival times. Conclusions and Clinical Importance The results support treatment using partial cystectomy and NSAIDs in cats with TCC.

【 授权许可】

Unknown