Associations between both legacy and alternative per- and polyfluoroalkyl substances and glucose-homeostasis: The Isomers of C8 health project in China

Environment International

卷:158

Guang-Hui Dong¹  Sarah Dee Geiger²  Peng-Xin Dong³  Yuan-Zhong Zhou⁴  Zheng-Min Qian⁵  Shi-Min Xiong⁶  Stephen Edward McMillin⁷  Bo-Yi Yang⁸  Chu Chu⁸  Yun-Ting Zhang⁸  Fan Su⁸  Mohammed Zeeshan⁸  Xiao-Wen Zeng⁸  Qing-Qing Li⁸  Wen-Ru Feng⁸  Yan-Qiu Ou⁹  Xu-Bo Shen¹⁰  Pei-En Zhou¹⁰  Zhi-Bin Wang¹¹ 

[1] Corresponding authors at: Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Preventive Medicine, School of Public Health, Sun Yat-sen University, 74 Zhongshan 2nd Road, Yuexiu District, Guangzhou 510080, China (G.H. Dong). School of Public Health, Zunyi Medical University, 6 Xuefu Road, Xinpuxin District, Zunyi 563060, China (Y. Zhou).;

[2] Social Justice, Saint Louis University, Saint Louis, MO 63104, USA;

[3] Department of Environmental Health Sciences, Laboratory of Human Environmental Epigenomes, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA;

[4] Department of Environmental Health, Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China;

[5] Department of Epidemiology and Biostatistics, College for Public Health &

[6] Department of Epidemiology, Guangdong Cardiovascular Institute, WHO Collaborating Center for Research and Training in Cardiovascular Diseases, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China;

[7] Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Champaign, IL 61820, USA;

[8] Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China;

[9] Nursing College, Guangxi Medical University, Nanning 530021, China;

[10] School of Public Health, Zunyi Medical University, Zunyi 563060, China;

[11] School of Social Work, College for Public Health and Social Justice, Saint Louis University, Saint Louis, MO 63103, USA;

关键词: PFASs;    PFAS alternatives;    Glucose-homeostasis marker;    Diabetes;    Sex-specific;    Multipollutant;   

DOI  :  

来源: DOAJ

【 摘 要 】

Background: Epidemiological studies on the associations of legacy per- and polyfluoroalkyl substances (PFASs) and glucose homeostasis remain discordant. Understanding of PFAS alternatives is limited, and few studies have reported joint associations of PFASs and PFAS alternatives. Objectives: To investigate associations of novel PFAS alternatives (chlorinated perfluoroalkyl ether sulfonic acids, Cl-PFESAs and perfluorobutanoic acid, PFBA) and two legacy PFASs (Perfluorooctanoic acid, PFOA and perfluorooctane sulfonate, PFOS) with glucose-homeostasis markers and explore joint associations of 13 legacy and alternative PFASs with the selected outcomes. Methods: We used cross-sectional data of 1,038 adults from the Isomers of C8 Health Project in China. Associations of PFASs and PFAS alternatives with glucose-homeostasis were explored in single-pollutant models using generalized linear models with natural cubic splines for PFASs. Bayesian Kernel Machine Regression (BKMR) models were applied to assess joint associations of exposures and outcomes. Sex-specific analyses were also conducted to evaluate effect modification. Results: After adjusting for confounders, both legacy (PFOA, PFOS) and alternative (Cl-PFESAs and PFBA) PFASs were positively associated with glucose-homeostasis markers in single-pollutant models. For example, in the total study population, estimated changes with 95% confidence intervals (CI) of fasting glucose at the 95th percentile of 6:2Cl-PFESA and PFOS against the thresholds were 0.90 (95% CI: 0.59, 1.21) and 0.44 (95% CI: 0.26, 0.62). Positive joint associations were found in BKMR models with 6:2Cl-PFESA contributing most. Sex-specific associations existed in both single- and multi-pollutant models. Conclusions: Legacy and alternative PFASs were positively associated with glucose-homeostasis markers. 6:2Cl-PFESA was the primary contributor. Sex-specific associations were also identified. These results indicate that joint associations and effect modification should be considered in risk assessment. However, further studies are recommended to strengthen our findings and to elucidate the mechanisms of action of legacy and alternative PFASs.

【 授权许可】

Unknown