An Intracellular Model of Hepatitis B Viral Infection: An In Silico Platform for Comparing Therapeutic Strategies

Viruses

卷:13

PeterG. Stockley¹  Nikesh Patel¹  Farzad Fatehi²  RichardJ. Bingham²  EricC. Dykeman²  Reidun Twarock² 

[1] Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT UK;

[2] York Cross-Disciplinary Centre for Systems Analysis, University of York, York YO10 5GE, UK;

关键词: hepatitis B virus;    intracellular model;    antiviral therapy;    packaging signal;    virus assembly;   

DOI  :  10.3390/v13010011

来源: DOAJ

【 摘 要 】

Hepatitis B virus (HBV) is a major focus of antiviral research worldwide. The International Coalition to Eliminate HBV, together with the World Health Organisation (WHO), have prioritised the search for a cure, with the goal of eliminating deaths from viral hepatitis by 2030. We present here a comprehensive model of intracellular HBV infection dynamics that includes all molecular processes currently targeted by drugs and agrees well with the observed outcomes of several clinical studies. The model reveals previously unsuspected kinetic behaviour in the formation of sub-viral particles, which could lead to a better understanding of the immune responses to infection. It also enables rapid comparative assessment of the impact of different treatment options and their potential synergies as combination therapies. A comparison of available and currently developed treatment options reveals that combinations of multiple capsid assembly inhibitors perform best.

【 授权许可】

Unknown