期刊论文详细信息
Journal of Integrative Agriculture 卷:13
Spectrum-Effect Relationship Between High Performance Liquid Chromatography Fingerprints and Anticoccidial Activities of a Compound Chinese Medicine
Fei-qun XUE1  Chen-zhong FEI2  Ke-yu ZHANG2  Sui XIAO2  Li-fang ZHANG2  Wen-li ZHENG2 
[1] Correspondence XUE Fei-qun, Tel: +86-21-34293460, Fax: +86-21-34293396;
[2] Key Laboratory of Veterinary Drug Safety Evaluation and Residues Research, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, P.R.China;
关键词: herb medicine;    fingerprint;    anticoccidial index;    spectrum-effect relationship;   
DOI  :  
来源: DOAJ
【 摘 要 】

Quality control and screening of active substances in traditional Chinese medicines have been performed using fingerprint analysis. The spectrum-effect relationship between chromatography fingerprints and efficacy of herbal drugs is considered as a potentially useful method for determining active ingredients in complex mixtures. The study was designed to develop a method for determining the bioactive components of a compound Chinese medicine called Tiefeng based on spectrum-effect relationships between high-performance liquid chromatography (HPLC) fingerprints and anticoccidial activities. Four peaks of the established HPLC fingerprint indicate the main bioactive components of this medicine. In addition, pharmacodynamic atlas was defined and used to assess the anticoccidial activity of Tiefeng from different sources for the first time. We found that the level of anticoccidial activity of Tiefeng was consistent with the degree of similarity between the pharmacodynamic atlas and chromatogram of any sample. Furthermore, effect of this medicine was related with the main active constituents, along with the origin and the harvesting time.

【 授权许可】

Unknown   

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