The Double-Edged Sword—How Human Papillomaviruses Interact With Immunity in Head and Neck Cancer

Frontiers in Immunology

卷:10

Min Zheng¹  Ya-Jie Tang²  Ya-ling Tang³  Yu Chen³  Xin-hua Liang⁴  Hao-fan Wang⁴  Sha-sha Wang⁴ 

[1] Department of Stomatology, Zhoushan Hospital, Wenzhou Medical University, Zhoushan, China;

[2] Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei Key Laboratory of Industrial Microbiology, Hubei Provincial Cooperative Innovation Center of Industrial Fermentation, Hubei University of Technology, Wuhan, China;

[3] State Key Laboratory of Oral Diseases, Department of Oral Pathology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology (Sichuan University), Chengdu, China;

[4] State Key Laboratory of Oral Diseases, Department of Oral and Maxillofacial Surgery, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology (Sichuan University), Chengdu, China;

关键词: human papilloma virus (HPV);    head and neck squamous cell carcinoma (HNSCC);    immune escape;    immune responses;    immunotherapy;   

DOI  :  10.3389/fimmu.2019.00653

来源: DOAJ

【 摘 要 】

Patients with human papilloma virus (HPV)-associated head and neck squamous cell carcinoma (HNSCC) have remarkably better prognosis, which differs from HPV-negative oropharyngeal squamous cell carcinoma (OPSCC) with respect to clinical, genomic, molecular, and immunological aspects, especially having the characteristics of high levels of immune cell infiltration and high degrees of immunosuppression. This review will summarize immune evasion mechanisms in HPV-positive HNSCC, analyze the host various immune responses to HPV and abundant numbers of infiltrating immune cell, and discuss the differences between HPV-positive HNSCC with cervical cancer. A deeper understanding of the immune landscape will help new concepts to emerge in immune-checkpoint oncology, which might be a valuable add-on to established concepts.

【 授权许可】

Unknown