Prognostic Potential of Heart Rate and Hypertension in Multiple Myeloma Patients

Frontiers in Cardiovascular Medicine

卷:8

Manyun Tang¹  Chaofeng Sun¹  Yang Yan²  Yongxin Li²  Jie Wang³  Mengchang Wang³  Limei Chen³  Yunxiang Long⁴  Jingzhuo Song⁵ 

[1] Atrial Fibrillation Centre and Department of Cardiovascular Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China;

[2] Department of Cardiovascular Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China;

[3] Department of Hematology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China;

[4] Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China;

[5] Department of Medical Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China;

关键词: multiple myeloma;    risk stratification;    heart rate;    hypertension;    cardiac rhythm abnormalities;   

DOI  :  10.3389/fcvm.2021.681484

来源: DOAJ

【 摘 要 】

Background: The prognosis of patients with multiple myeloma (MM) is variable and partly depends on their cardiovascular status. The presence of arrhythmias can lead to worse outcomes. Therefore, this study aimed to evaluate the potential of heart rate (HR) and hypertension in predicating the outcomes of MM patients.Methods: This study retrospectively enrolled patients with MM between January 1, 2010, and December 31, 2018, at the First Affiliated Hospital of Xi'an Jiaotong University. The endpoint was all-cause mortality. The Pearson's chi-square test was used to assess the association between hypertension and outcomes. Univariate and multivariate Cox proportional hazards models were developed to evaluate the relationship between HR and all-cause mortality.Results: A total of 386 patients were included. The mean HR was 83.8 ± 23.1 beats per minute (bpm). Patients with HR >100 bpm had a higher all-cause mortality (79.4%, 50/63) than those with 60 ≤ HR ≤ 100 bpm (39.9%, 110/276) and <60 bpm (19.1%, 9/47) (p < 0.001). Subgroup analysis based on the International Staging System and sex revealed similar relationships (p < 0.01). When stratified by age, patients with HR >100 bpm had higher all-cause mortality than those with a lower HR when age was <65 years or 65–75 years (p < 0.001) but not >75 years. The proportion of patients with hypertension was 54.7% (211/386). However, hypertension was not associated with all-cause mortality in MM patients (χ2=1.729, p > 0.05). MM patients with HR >100 bpm had the highest all-cause mortality.Conclusions: The prognostic potential of HR may be useful in aiding risk stratification and promoting the management of these patients.

【 授权许可】

Unknown