Effect of semen sojae germinatum on experimental osteoarthritis in the rabbit knee

Bangladesh Journal of Pharmacology

卷:8

Bingshu He¹  Jun Wang² 

[1] Department of Orthopedic Surgery, Hubei Woman and Child Hospital, Wuhan;

[2] Department of Pharmacy, Medical College, Wuhan University of Science and Technology, Wuhan;

关键词: Matrix metalloproteinase;    Osteoarthritis;    Pro-inflammatory mediator;    Semen sojae germinatum;   

DOI  :  10.3329/bjp.v8i4.16446

来源: DOAJ

【 摘 要 】

As a complementary therapeutic approach, soy ingredients, such as soy protein and soybean unsaponifiables, recently attract more attention for relieving symptoms of osteoarthritis (OA). Semen sojae germinatum (SSG) processed from bean-sprout coming from germinating Glycine maxL. Merr. is a traditional Chinese herbal medicine treating knee OA. We evaluated the effect of SSG as feed on the development of anterior cruciate ligament transaction (ACLT) -induced knee OA in rabbits. The results showed that SSG reduced the severity of cartilage degeneration in macroscopic grading scale, and delayed the degradation of the cartilage matrix. The contents of prostaglandin E2 (PGE2), nitric oxide (NO), tumor necrosis factor (TNF)-α, interleukin-6(IL-6) and IL-1β in synovial fluid, mRNA and protein expressions of matrix metalloproteinases (MMP)-3, MMP-13 in cartilage were effectively decreased in SSG group. These results demonstrate that SSG had a protective effect against the development of knee OA.

【 授权许可】

Unknown