Magnesium Metabolism in Chronic Alcohol-Use Disorder: Meta-Analysis and Systematic Review

Nutrients

卷:13

Giorgio Treglia¹  Pietro Camozzi²  Simone Janett²  Pietro B. Faré³  Mario G. Bianchetti⁴  Flora O. Vanoni⁴  Sebastiano A. G. Lava⁵  Gregorio P. Milani⁶  Carlo Agostoni⁶ 

[1] Academic Education, Research and Innovation Area, General Directorate, Ente Ospedaliero Cantonale, 6500 Bellinzona, Switzerland;

[2] Department of Internal Medicine, Ente Ospedaliero Cantonale, 6500 Bellinzona, Switzerland;

[3] Department of Internal Medicine, Ente Ospedaliero Cantonale, 6600 Locarno, Switzerland;

[4] Family Medicine Institute, Faculty of Biomedical Science, Università della Svizzera Italiana, 6900 Lugano, Switzerland;

[5] Pediatric Cardiology Unit, Department of Pediatrics, Centre Hospitalier Universitaire Vaudois, University of Lausanne, 1011 Lausanne, Switzerland;

[6] Pediatric Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy;

关键词: magnesium;    hypomagnesemia;    depletion;    kidney;    diet;    alcohol-use;   

DOI  :  10.3390/nu13061959

来源: DOAJ

【 摘 要 】

Chronic alcohol-use disorder has been imputed as a possible cause of dietary magnesium depletion. The purpose of this study was to assess the prevalence of hypomagnesemia in chronic alcohol-use disorder, and to provide information on intracellular magnesium and on its renal handling. We carried out a structured literature search up to November 2020, which returned 2719 potentially relevant records. After excluding non-significant records, 25 were retained for the final analysis. The meta-analysis disclosed that both total and ionized circulating magnesium are markedly reduced in chronic alcohol-use disorder. The funnel plot and the Egger’s test did not disclose significant publication bias. The I²-test demonstrated significant statistical heterogeneity between studies. We also found that the skeletal muscle magnesium content is reduced and the kidney’s normal response to hypomagnesemia is blunted. In conclusion, magnesium depletion is common in chronic alcohol-use disorder. Furthermore, the kidney plays a crucial role in the development of magnesium depletion.

【 授权许可】

Unknown