Role of TSH on Urinary Calcium Excretion In Post Menopausal Women of South Indian Population

Journal of Clinical and Diagnostic Research

卷:7

Amrutha P V¹  Sathiya R²  Niranjan G³  Sathishbabu M⁴  Srinivasan A R⁵  Ramesh R⁵ 

[1] 2nd Year MBBS Student.;

[2] 3rd Year MSc (Medical Biochemistry) Student, Mahatma Gandhi Medical College and Research Institute (MGMCRI), Sri Balaji Vidyapeeth (SBV)University, Pillaiyarkuppam, Puducherry-607402, India.;

[3] Assistant Professor, Department of Biochemistry, Mahatma Gandhi Medical College and Research Institute (MGMCRI), Sri Balaji Vidyapeeth (SBV) University, Pillaiyarkuppam, Puducherry-607402, India.;

[4] Assistant Professor, Department of Biochemistry.;

[5] Professor, Department of Biochemistry.;

关键词: thyroid stimulating hormone;    post menopausal women;    urinary calcium;    urinary calcium/creatinine ratio;   

DOI  :  10.7860/JCDR/2013/5290.3056

来源: DOAJ

【 摘 要 】

Background: Unforeseen aberrations in the hormonal statusduring the early postmenopausal period are responsible forseveral complications including osteoporosis. Thyroid Stimulating Hormone (TSH) receptors are isolated from various tissues including the bone. A low serum TSH level is known tostimulate osteoclastic activity in bone and accelerate boneresorption. Urinary calcium/creatinine (UCa/Cr) excretion ratio could be an indirect and an early indicator of loss of BoneMineral Density (BMD). With this background, this study wasplanned to explore the association of serum TSH levels withthe UCa/Cr excretion ratio.Methods: Forty eight women in the postmenopausal agegroup, with their menopausal age not more than seven yearsof duration were included in this study. Based on their TSH values, these subjects were divided into two groups A (TSH<0.5mIU/L) and B (TSH>0.5mIU/L). Urinary calcium, UCa/Cr excretion ratio, serum phosphorous, calcium and calcium phosphorous multiplication products were estimated and comparedbetween the two groups.Results: Twenty two (46%) women were biochemically asymptomatic hyperthyroid cases and Twenty six (54%) were euthyroid. This study documents high UCa/Cr in Group A comparedto that of Group B (p<0.05). We also observed significant negative correlation of TSH with UCa/Cr excretion ratio (p=0.041, r= -0.43).Conclusion: Low serum TSH levels were associated with increased UCa/Cr excretion ratio in postmenopausal women ofSouth Indian population.

【 授权许可】

Unknown