Rationale for MYC imaging and targeting in pancreatic cancer

EJNMMI Research

卷:11

Dieter Saur¹  Ulrich Keller¹  Matthias Wirth¹  Günter Schneider² 

[1] German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK);

[2] Medical Clinic and Policlinic II, Klinikum Rechts Der Isar, TU Munich;

关键词: Pancreatic cancer;    Precision oncology;    MYC;    Targeted therapies;   

DOI  :  10.1186/s13550-021-00843-1

来源: DOAJ

【 摘 要 】

Abstract The incidence and lethality of pancreatic ductal adenocarcinoma (PDAC) will continue to increase in the next decade. For most patients, chemotherapeutic combination therapies remain the standard of care. The development and successful implementation of precision oncology in other gastrointestinal tumor entities point to opportunities also for PDAC. Therefore, markers linked to specific therapeutic responses and important subgroups of the disease are needed. The MYC oncogene is a relevant driver in PDAC and is linked to drug resistance and sensitivity. Here, we update recent insights into MYC biology in PDAC, summarize the connections between MYC and drug responses, and point to an opportunity to image MYC non-invasively. In sum, we propose MYC-associated biology as a basis for the development of concepts for precision oncology in PDAC.

【 授权许可】

Unknown