Human aldo-keto reductases: structure, substrate specificity and roles in tumorigenesis

Biomolecular Concepts

卷:2

Cao Deliang¹  Ma Jun¹ 

[1] Department of Medical Microbiology, Immunology and Cell Biology, Simmons Cancer Institute, Southern Illinois University School of Medicine, 913 N. Rutledge Street, Springfield, IL 62794, USA;

关键词: aldo-keto reductases;    akr1b1;    akr1b10;    akr1c;    anticancer agents;    carbonyls;    polycyclic aromatic hydrocarbons;    prostaglandins;    retinaldehyde;    tumorigenesis;   

DOI  :  10.1515/bmc.2011.010

来源: DOAJ

【 摘 要 】

The aldo-keto reductase (AKR) superfamily consists of over 150 protein members sharing similar structure and enzymatic activities. To date, 13 human AKRs have been identified, and they participate in xenobiotic detoxification, biosynthesis and metabolism. Increasing evidence suggests the involvement of human AKR proteins in cancer development, progression and treatment. Some proteins demonstrate multiple functional features in addition to being a reductase for carbonyl groups. This review article discusses the most recent progress made in the study of humans AKRs.

【 授权许可】

Unknown