Molecular Mechanisms of 5-Fluorocytosine Resistance in Yeasts and Filamentous Fungi

Journal of Fungi

卷:7

Sybren de Hoog¹  Roger J. M. Brüggemann¹  Willem J. G. Melchers²  Paul E. Verweij²  Fatima Zohra Delma²  Jochem B. Buil²  Abdullah M. S. Al-Hatmi³ 

[1] Centre of Expertise in Mycology Radboudumc/CWZ, Radboudumc Center for Infectious Diseases (RCI), 6252 AG Nijmegen, The Netherlands;

[2] Department of Medical Microbiology, Radboud University Medical Centre, 6252 AG Nijmegen, The Netherlands;

[3] Natural & Medical Sciences Research Center, University of Nizwa, Nizwa 616, Oman;

关键词: 5-fluorocytosine;    resistance;    molecular mechanisms;   

DOI  :  10.3390/jof7110909

来源: DOAJ

【 摘 要 】

Effective management and treatment of fungal diseases is hampered by poor diagnosis, limited options for antifungal therapy, and the emergence of antifungal drug resistance. An understanding of molecular mechanisms contributing to resistance is essential to optimize the efficacy of currently available antifungals. In this perspective, one of the oldest antifungals, 5-fluorocytosine (5-FC), has been the focus of recent studies applying advanced genomic and transcriptomic techniques to decipher the order of events at the molecular level that lead to resistance. These studies have highlighted the complexity of resistance and provided new insights that are reviewed in the present paper.

【 授权许可】

Unknown