Environmental and Nutritional Effects Regulating Adipose Tissue Function and Metabolism Across Generations

Advanced Science

卷:6

Wenfei Sun¹  Daria Peleg‐Raibstein¹  Christian Wolfrum¹  Ferdinand von Meyenn¹ 

[1] Department of Health Science and Technologies ETH Zürich Schorenstrasse 16 Schwerzenbach CH‐8603 Switzerland;

关键词: adipose tissue;    diabetes;    epigenetics;    obesity;    transgenerational epigenetic inheritance;   

DOI  :  10.1002/advs.201900275

来源: DOAJ

【 摘 要 】

Abstract The unabated rise in obesity prevalence during the last 40 years has spurred substantial interest in understanding the reasons for this epidemic. Studies in mice and humans have demonstrated that obesity is a highly heritable disease; however genetic variations within specific populations have so far not been able to explain this phenomenon to its full extent. Recent work has demonstrated that environmental cues can be sensed by an organism to elicit lasting changes, which in turn can affect systemic energy metabolism by different epigenetic mechanisms such as changes in small noncoding RNA expression, DNA methylation patterns, as well as histone modifications. These changes can directly modulate cellular function in response to environmental cues, however research during the last decade has demonstrated that some of these modifications might be transmitted to subsequent generations, thus modulating energy metabolism of the progeny in an inter‐ as well as transgenerational manner. In this context, adipose tissue has become a focus of research due to its plasticity, which allows the formation of energy storing (white) as well as energy wasting (brown/brite/beige) cells within the same depot. In this Review, the effects of environmental induced obesity with a particular focus on adipose tissue are discussed.

【 授权许可】

Unknown