Systematic review and meta-analysis of propofol versus barbiturates for controlling refractory status epilepticus

BMC Neurology

卷:19

Yu Lu¹  Yun Yu¹  Qing Zhang¹  Hongli Yue¹ 

[1] Department of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University;

关键词: Propofol;    Barbiturates;    Refractory status epilepticus;    RSE;    Meta-analysis;   

DOI  :  10.1186/s12883-019-1281-y

来源: DOAJ

【 摘 要 】

Abstract Background Several studies have compared the efficacy and safety of propofol and barbiturates in the treatment of refractory status epilepticus (RSE). This study aims to quantitatively assess the advantages and disadvantages of propofol and barbiturates in controlling RSE. Methods We searched for studies with relevant data from the PubMed, Embase, Ovid, Cochrane Library, Springer Link, Web of Science, and China National Knowledge Infrastructure databases. By calculating odds ratios and standardized mean differences with 95% confidence intervals, we assessed the disease control rate (DCR), case fatality rate (CFR), average control time (ACT), average tracheal intubation placement time (ATIPT), and incidence of hypotension between propofol and barbiturates in treating RSE. Results Seven studies with 261 patients were included in this analysis. Meta-analysis revealed that the DCR of propofol was higher than that of barbiturates (p < 0.001) and that the CFR (p = 0.382) between the two treatment did not significantly differ in controlling RSE. Propofol shortened the ACT (p < 0.001) of RSE and reduced the ATIPT (p < 0.001) of patients with RSE more extensively than did barbiturates and did not increase the incidence of hypotension (p = 0.737). Conclusions In comparison with barbiturates, propofol can control RSE and shorten ATIPT in a more efficient and timely manner. Moreover, the drug does not increase the incidence of hypotension and CFR.

【 授权许可】

Unknown