Advances in the Application of Supramolecular Hydrogels for Stem Cell Delivery and Cartilage Tissue Engineering

Frontiers in Bioengineering and Biotechnology

卷:8

Jing Ye²  Bing-Bing Xu²  Jia-Kuo Yu²  Meng Yang²  Yi-Fan Song²  Ji-ying Zhang²  Xin Yan²  You-Rong Chen²  Xing Wang³ 

[1] Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China;

[2] Knee Surgery Department of the Institute of Sports Medicine, Peking University Third Hospital, Beijing, China;

[3] University of Chinese Academy of Sciences, Beijing, China;

关键词: supramolecular hydrogels;    stem cell delivery;    extracellular matrix;    cartilage tissue;    tissue engineering;   

DOI  :  10.3389/fbioe.2020.00847

来源: DOAJ

【 摘 要 】

Cartilage defects pose a great threat to the health of the aging population. Cartilage has limited self-regeneration ability because it lacks blood vessels, nerves and lymph. To achieve efficient cartilage regeneration, supramolecular hydrogels are used in medical applications and tissue engineering as they are tunable and reversible in nature. Moreover, they possess supramolecular interactions which allow the incorporation of cells. These hydrogels present great potential for tissue engineering-based therapies. This review presents advances in the development of stem cell-laden supramolecular hydrogels. We discuss new possibilities for stem cell therapy and their uses in cartilage tissue engineering. Gray areas and future perspectives are discussed.

【 授权许可】

Unknown