In-vitro experiments to characterize ventricular electromechanics

Current Directions in Biomedical Engineering

卷:2

Plank Gernot¹  Hofer Ernst¹  Arnold Robert¹  Prassl Anton J.¹ 

[1] Medical University of Graz, Institute of Biophysics, Harrachgasse 21, 8010 Graz, Austria;

关键词: conduction velocity;    stress-strain relationship;    ventricular mechanics;   

DOI  :  10.1515/cdbme-2016-0059

来源: DOAJ

【 摘 要 】

Computer simulation turns out to be beneficial when clinical data lack spatio-temporal resolution or parameters cannot be measured at all. To derive trustworthy results, these in-silico models have to thoroughly parameterized and validated. In this work we present data from a simplified in-vitro setup for characterizing ventricular electromechanics. Right ventricular papillary muscles from New Zealand rabbits were isolated and stretched from slack length to lmax, i.e. the muscle length at maximum active force development. Active stress development showed an almost linear increase for moderate strain (90–100% of lmax) and a significant decrease for larger strain (100–105% of lmax). Passive strain development showed a nonlinear increase. Conduction velocity CV showed an increase of ≈10% between low and moderate strain and no significant decrease beyond. Fitting active active stress-strain relationship using a 5th-order polynomial yielded adequate results for moderate and high strain values, whereas fitting using a logistic function yielded more reasonable results for low strain values. Passive stress-strain relationship was satisfactorily fitted using an exponential function.

【 授权许可】

Unknown