Association between abdominal adiposity and subclinical measures of left-ventricular remodeling in diabetics, prediabetics and normal controls without history of cardiovascular disease as measured by magnetic resonance imaging: results from the KORA-FF4 Study

Cardiovascular Diabetology

卷:17

Wolfgang Rathmann¹  Christopher L. Schlett²  Carolyn Arndt²  Jürgen Machann³  Roberto Lorbeer⁴  Sigrid Auweter⁴  Fabian Bamberg⁴  Holger Hetterich⁴  Annette Peters⁵  Birgit Linkohr⁵ 

[1] Department of Biometry and Epidemiology, German Diabetes Center;

[2] Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg;

[3] Department of Diagnostic and Interventional Radiology, University of Tuebingen;

[4] Institute of Clinical Radiology, Ludwig-Maximilian-University Hospital;

[5] Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health;

关键词: Magnetic resonance imaging;    Intra-abdominal fat;    Fatty liver;    Ventricular remodeling;    Diabetes mellitus;   

DOI  :  10.1186/s12933-018-0721-0

来源: DOAJ

【 摘 要 】

Abstract Objectives Local, abdominal fat depots may be related to alterations in cardiac function and morphology due to a metabolic linkage. Thus, we aimed to determine their association with subtle cardiac changes and the potential interaction with hyperglycemic metabolic states. Methods Subjects from the general population and without history of cardiovascular disease were drawn from the Cooperative Health Research in the Region of Augsburg FF4 cohort and underwent 3 T cardiac and body MRI. Measures of abdominal adiposity such as hepatic proton-density fat fraction [PDFFhepatic], subcutaneous (SAT) and visceral abdominal fat (VAT) as well as established cardiac left-ventricular (LV) measures including LV remodeling index (LVCI) were derived. Associations were determined using linear regression analysis based on standard deviation normalized predictors. Results Among a total of 374 subjects (56.2 ± 9.1 years, 58% males), 49 subjects had diabetes, 99 subjects had prediabetes and 226 represented normal controls. Only subtle cardiac alterations were observed (e.g. LVCI: 1.13 ± 0.30). While SAT was not associated, increasing VAT and increasing PDFFhepatic were independently associated with increasing LVCI (β = 0.11 and 0.06, respectively), decreasing LV end-diastolic volume (β = − 6.70 and 3.23, respectively), and decreasing LV stroke volume (β = − 3.91 and − 2.20, respectively). Hyperglycemic state did not modify the associations between VAT or PDFF and LV measures (interaction term: all p ≥ 0.29). Conclusion In a healthy population, VAT but also PDFFhepatic were associated with subclinical measures of LV remodeling without evidence for a modifying effect of hyperglycemic state.

【 授权许可】

Unknown