Closed Loop Brain Model of Neocortical Information Based Exchange

Frontiers in Neuroanatomy

卷:10

James eKozloski¹ 

[1] IBM Research;

关键词: Basal Ganglia;    Dopamine;    Neocortex;    Thalamus;    brain modeling;    information based exchange;   

DOI  :  10.3389/fnana.2016.00003

来源: DOAJ

【 摘 要 】

Here we describe an information based exchange' model of brain function that ascribes to neocortex, basal ganglia, and thalamus distinct network functions. The model allows us to analyze whole brain system set point measures, such as the rate and heterogeneity of transitions in striatum and neocortex, in the context of neuromodulation and other perturbations. Our closed-loop model is grounded in neuroanatomical observations, proposing a novel Grand Loop through neocortex, and invokes different forms of plasticity at specific tissue interfaces and their principle cell synapses to achieve these transitions. By implementing a system for maximum information based exchange of action potentials between modeled neocortical areas, we observe changes to these measures in simulation. We hypothesize that similar dynamic set points and modulations exist in the brain's resting state activity, and that different modifications to information based exchange may shift the risk profile of different component tissues, resulting in different neurodegenerative diseases. This model is targeted for further development using IBM's Neural Tissue Simulator, which allows scalable elaboration of networks, tissues, and their neural and synaptic components towards ever greater complexity and biological realism.

【 授权许可】

Unknown