Molecular Interaction, Chain Conformation, and Rheological Modification During Electrospinning of Hyaluronic Acid Aqueous Solution

Membranes

卷:10

Ying Liu¹  Xuhong Chen²  Shanshan Xu²  CharlesC. Han²  Hao Chen²  Huiying Chen²  Aihua He³  Junxing Li³  Jun Luo³  Xin Liu³ 

[1] CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety & CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing 100190, China;

[2] Institute for Advanced Study, Shenzhen University, Shenzhen 518060, China;

[3] State Key Laboratory of Polymer Physics and Chemistry, Joint Laboratory of Polymer Science and Materials, Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China;

关键词: electrospinning;    hyaluronic acid (HA);    polyethylene oxide (PEO);    chain entanglement;    tissue engineering;   

DOI  :  10.3390/membranes10090217

来源: DOAJ

【 摘 要 】

Most of natural water-soluble polymers are difficult to electrospin due to their specific chain conformation in aqueous solution, which limits their applications. This study investigated the effects of polyethylene oxide (PEO) on the electrospinning of hyaluronic acid (HA) in HA/PEO aqueous solutions. The rheological properties of HA/PEO aqueous solutions showed polymer chain entanglement in HA was the essential factor affecting its electrospinnability. Wide-angle X-ray scattering and differential scanning calorimetry analyses of a PEO crystal showed different crystallization behavior of the PEO chain with different molecular weight, which indicates different interaction with HA. A schematic molecular model has been proposed to explain the effect of PEO on the chain conformation of HA along with the relationship between electrospinnability and chain entanglement. PEO with a relatively high molecular weight with limited crystal formation formed extensive chain entanglements with HA, while PEO with relatively low molecular weight weakened the interactions among HA chains. The findings of this study provide a wide perspective to better understand the electrospinning mechanisms of natural polyelectrolytes and usage in tissue engineering.

【 授权许可】

Unknown