Comparative Therapeutic Properties of Garlic Extract and Metformin on Hyperglycaemia, Hypercholesterolaemia, and Hypertriglyceridaemia in Alloxan-induced Type1-like Diabetic Rats

Kemija u Industriji

卷:71

Djamel Atsamnia¹  Mabrouk Hamadache¹  Salah Hanini¹  Othmane Benkortbi¹  Karine Benachour²  Dahmane Oukrif³ 

[1] Biomaterials and Transport Phenomena Laboratory (LBMPT), Dr Yahia Fares University of Médéa, Algeria;

[2] Laboratory of Experimental Biology and Pharmacology, Faculty of Sciences, Dr Yahia Fares University of Médéa, Algeria;

[3] University College London, Department of Pathology, UK;

关键词: alloxan;    diabetes;    garlic extract;    glycaemia;    metformin;   

DOI  :  10.15255/KUI.2021.035

来源: DOAJ

【 摘 要 】

The current pilot study was conducted to compare the triple effect of garlic extract and metformin on hyperglycaemia, hypercholesterolaemia, and hypertriglyceridaemia in alloxan-induced type 1-like diabetic rats. Wistar rats were randomly divided into four groups. Control group included normal rats. The second group included alloxan-induced type 1-like diabetic rats, receiving no treatment. The other two groups of diabetic rats were orally treated with 0.75 g of garlic extract per kg of body weight and 0.05 of metformin g per kg of body weight respectively for four weeks. The pharmacological impact of garlic compounds on serum glucose and lipids as opposed to the glucose-lowering and lipid-lowering was highlighted in these experiments. These results revealed that garlic extract has a triple action on hyperglycaemia, hypertriglyceridemia, and hypercholesterolemia. Its effect on hyperglycaemia is long lasting, and more pronounced compared to the metformin. Interestingly, it had a regulatory effect on glycaemia as highlighted in the control group.

【 授权许可】

Unknown