Gut Microbiota and Colon Cancer: A Role for Bacterial Protein Toxins?

International Journal of Molecular Sciences

卷:21

Carla Fiorentini¹  Francesca Carlini²  ElenaAngela Pia Germinario²  Alessia Fabbri²  Zaira Maroccia²  Sara Travaglione² 

[1] Association for Research on Integrative Oncology Therapies (ARTOI), Via Ludovico Micara, 73, 00165 Rome, Italy;

[2] Department of Cardiovascular, Endocrine-Metabolic Diseases and Aging, Istituto Superiore di Sanità, Viale Regina Elena, 299, 00161 Rome, Italy;

关键词: colorectal neoplasms;    gut microbiota;    bacterial protein toxin;    bacterial infections;    inflammation;    carcinogenesis;   

DOI  :  10.3390/ijms21176201

来源: DOAJ

【 摘 要 】

Accumulating evidence indicates that the human intestinal microbiota can contribute to the etiology of colorectal cancer. Triggering factors, including inflammation and bacterial infections, may favor the shift of the gut microbiota from a mutualistic to a pro-carcinogenic configuration. In this context, certain bacterial pathogens can exert a pro-tumoral activity by producing enzymatically-active protein toxins that either directly induce host cell DNA damage or interfere with essential host cell signaling pathways involved in cell proliferation, apoptosis, and inflammation. This review is focused on those toxins that, by mimicking carcinogens and cancer promoters, could represent a paradigm for bacterially induced carcinogenesis.

【 授权许可】

Unknown