Nanotechnological approaches to enhance the bioavailability and therapeutic efficacy of green tea polyphenols

Journal of Functional Foods

卷:34

Neeraja Recharla¹  Chulkyoon Mok¹  Sanghoon Ko²  Jin Liang³  Pradeep Puligundla³ 

[1] Biotechnology, Gachon University, Seongnam-si, Gyeonggi-do 13120, Republic of Korea;

[2] Corresponding author.;

[3] Department of Food Science &

关键词: Green tea;    Polyphenols;    Bioavailability;    Nanoencapsulation;    Solid lipid nanoparticle;    Therapeutic efficacy;   

DOI  :  

来源: DOAJ

【 摘 要 】

Green tea contains numerous bioactive compounds that may provide multiple health benefits, including antioxidative, anti-inflammatory, anti-carcinogenic, anti-proliferative, anti-hypertensive, antithrombogenic and lipid-lowering effects. Most of the chemopreventive and therapeutic effects of green tea extracts have been attributed to the presence of different polyphenolic bioactives, especially catechins, in their composition. Although these polyphenolic compounds have been shown promising therapeutic effects under in vitro conditions, they met with limited efficacy in clinical settings due to various reasons such as poor oral absorption and bioavailability. Different techniques have been proposed to improve the bioavailability of green tea polyphenols. Among such strategies, nanoparticle-based delivery systems are novel and promising tools. This review is intended to discuss the advances related to improvement of in vitro and in vivo bioavailability of green tea polyphenols using nanotechnological approaches, which in turn would aid in enhancing their therapeutic efficacy.

【 授权许可】

Unknown