Recent advances in fluorescence-based in vivo flow cytometry

Journal of Innovative Optical Health Sciences

卷:12

Feng Liu¹  Lianqing Zhu¹  Mingli Dong¹  Kai Pang¹  Xunbin Wei²  Bobo Gu² 

[1] Beijing Key Laboratory for Optoelectronic Measurement Technology, Key Laboratory for Optoelectronic Measurement Technology and Instruments of Ministry of Education, Beijing Information Science & Technology University, Beijing 100192, P. R. China;

[2] Med-X Research Institute and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, P. R. China;

关键词: in vivo flow cytometry;    circulating tumor cells (ctcs);    ctc clusters;    nanoparticles;    fluorescence;   

DOI  :  10.1142/S1793545819300088

来源: DOAJ

【 摘 要 】

The fluorescence-based in vivo flow cytometry (IVFC) is an emerging tool to monitor circulating cells in vivo. As a noninvasive and real-time diagnostic technology, the fluorescence-based IVFC allows long-term monitoring of circulating cells without changing their native biological environment. It has been applied for various biological applications (e.g., monitoring circulating tumor cells). In this work, we will review our recent works on fluorescence-based IVFC. The operation principle and typical biological applications will be introduced. In addition, the recent advances in IVFC flow cytometry based on photoacoustic effects and other label-free detection methods such as imaging-based methods, diffuse-light methods, hybrid multimodality methods and multispectral methods are also summarized.

【 授权许可】

Unknown