Differences in Brain Volume between Metabolically Healthy and Unhealthy Overweight and Obese Children: The Role of Fitness

Journal of Clinical Medicine

卷:9

KirkI. Erickson¹  CharlesH. Hillman²  ArthurF. Kramer²  Pontus Henriksson³  Andrés Catena⁴  José Gómez-Vida⁵  José Maldonado⁶  Idoia Labayen⁷  Juan Verdejo-Román⁸  Jose Mora-Gonzalez⁹  Irene Esteban-Cornejo⁹  FranciscoB. Ortega⁹  Cristina Cadenas-Sanchez⁹  JairoH. Migueles⁹ 

[1] Brain Aging & Cognitive Health Lab, Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA;

[2] Center for Cognitive and Brain Health, Department of Psychology, Northeastern University, Boston, MA 02115, USA;

[3] Department of Biosciences and Nutrition at NOVUM, Karolinska Institutet, 14183 Huddinge, Sweden;

[4] Department of Experimental Psychology, Mind, Brain and Behavior Research Center (CIMCYC), University of Granada, 18011 Granada, Spain;

[5] Department of Pediatrics, San Cecilio Hospital, 18016 Granada, Spain;

[6] Department of Pediatrics, School of Medicine, University of Granada, 18016 Granada, Spain;

[7] Institute for Innovation & Sustainable Development in Food Chain (IS-FOOD), Public University of Navarra, 31006 Pamplona, Spain;

[8] Mind, Brain and Behavior Research Center (CIMCYC), University of Granada, 18011 Granada, Spain;

[9] PROFITH “PROmoting FITness and Health through Physical Activity” Research Group, Department of Physical and Sports Education, Faculty of Sport Sciences, University of Granada, 18071 Granada, Spain;

关键词: academic achievement;    cardiorespiratory fitness;    global volume;    gray matter;    regional volume;   

DOI  :  10.3390/jcm9041059

来源: DOAJ

【 摘 要 】

The aim of this study was to examine whether metabolically healthy overweight/obese children have greater global and regional gray matter volumes than their metabolically unhealthy peers. We further examined the association between gray matter volume and academic achievement, along with the role of cardiorespiratory fitness in these associations. A total of 97 overweight/obese children (10.0 ± 1.2 years) participated. We classified children as metabolically healthy/unhealthy based on metabolic syndrome cut-offs. Global and regional brain volumes were assessed by magnetic resonance imaging. Academic achievement was assessed using the Woodcock-Muñoz standardized test. Cardiorespiratory fitness was assessed by the 20 m shuttle run test. Metabolically healthy overweight/obese (MHO) children had greater regional gray matter volume compared to those who were metabolically unhealthy (MUO) (all p ≤ 0.001). A similar trend was observed for global gray matter volume (p = 0.06). Global gray matter volume was positively related to academic achievement (β = 0.237, p = 0.036). However, all the associations were attenuated or disappeared after adjusting for cardiorespiratory fitness (p > 0.05). The findings of the present study support that metabolically healthy overweight/obese children have greater gray matter volume compared to those that are metabolically unhealthy, which is in turn related to better academic achievement. However, cardiorespiratory fitness seems to explain, at least partially, these findings.

【 授权许可】

Unknown